Walker Cole International is partnering with a leading biopharmaceutical company to hire a Principal Scientist (Technical Lead), focused on product characterisation. This laboratory-based position plays a key role in supporting the development of complex biologics, combining technical leadership with hands-on scientific expertise.
Key Responsibilities of the Principal Scientist, Technical Lead:
* Establishing and executing internal characterisation strategies to support the development of biologics.

* Designing and implementing advanced analytical techniques, with a focus on mass spectrometry, to investigate structure, impurities, and degradation pathways.

* Developing characterisation approaches across multiple molecule types including ADCs, fusion proteins, and bispecific antibodies.

* Acting as the technical lead for both in-house and outsourced analytical activities, including oversight of external partners.

* Driving continuous improvements in analytical processes, systems, and technologies.

* Preparing and reviewing documentation to support regulatory submissions and internal quality standards.

Key requirements for the Principal Scientist, Technical Lead position include:
* Significant experience developing and applying mass spectrometry methods for biologics characterisation.

* In-depth understanding of protein chemistry, including post-translational modifications and degradation mechanisms.

* Experience supporting CMC development and working across cross-functional teams.

* Strong track record in analytical method development and optimisation, including peptide mapping and HCP profiling.

* Ability to lead scientific strategy while managing both internal and external technical relationships.

Biopharmaceuticals | Mass Spectrometry | Analytical Development | Biologics Characterisation | Protein Chemistry | CMC | Advanced Modalities | CDMO | GMP | Structural Analysis